Evaluating the evidence for macrophage presence in skeletal muscle and its relation to insulin resistance in obese mice and humans: a systematic review protocol
| Autor: | M. Constantine Samaan, Kuan-Wen Wang, Pei-Wen Wang, Laura Banfield, Lehana Thabane, Meha Bhatt, Srikesh Rudrapatna, Rachel Bierbrier |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Anti-Inflammatory Agents lcsh:Medicine Skeletal muscle Mice Obese Adipose tissue Inflammation Type 2 diabetes Bioinformatics General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences Insulin resistance Diabetes mellitus medicine Animals Humans Hypoglycemic Agents Insulin Obesity Molecular Targeted Therapy Animal testing lcsh:Science (General) Muscle Skeletal lcsh:QH301-705.5 Immunometabolism business.industry Macrophages lcsh:R General Medicine medicine.disease Research Note Disease Models Animal 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Adipose Tissue Diabetes Mellitus Type 2 Immunology Anti-Obesity Agents medicine.symptom business lcsh:Q1-390 Systematic Reviews as Topic |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 10, Iss 1, Pp 1-6 (2017) |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-017-2686-6 |
| Popis: | Objectives The current global rates of obesity and type 2 diabetes are staggering. In order to implement effective management strategies, it is imperative to understand the mechanisms of obesity-induced insulin resistance and diabetes. Macrophage infiltration and inflammation of the adipose tissue in obesity is a well-established paradigm, yet the role of macrophages in muscle inflammation, insulin resistance and diabetes is not adequately studied. In this systematic review, we will examine the evidence for the presence of macrophages in skeletal muscle of obese humans and mice, and will assess the association between muscle macrophages and insulin resistance. We will identify published studies that address muscle macrophage content and phenotype, and its association with insulin resistance. We will search MEDLINE/PubMed, EMBASE, and Web of Science for eligible studies. Grey literature will be searched in ProQuest. Quality assessment will be conducted using the Systematic Review Centre for Laboratory Animal Experimentation risk of bias Tool for animal studies. Results The findings of this systematic review will shed light on immune-metabolic crosstalk in obesity, and allow the consideration of targeted therapies to modulate muscle macrophages in the treatment and prevention of diabetes. The review will be published in a peer-reviewed journal and presented at conferences. Electronic supplementary material The online version of this article (doi:10.1186/s13104-017-2686-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|