Polydimethylsiloxane: a new contrast material for localization of occult breast lesions
| Autor: | Geraldo Sérgio Farinazzo Vitral, Nádia Rezende Barbosa Raposo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty ROLL technique media_common.quotation_subject Radiography Mammoplasty macromolecular substances Lesion surgery chemistry.chemical_compound Breast cancer breast cancer Iodinated contrast medicine Contrast (vision) Radiology Nuclear Medicine and imaging media_common Polydimethylsiloxane business.industry technology industry and agriculture radiological contrast medicine.disease Contrast medium Oncology chemistry medicine.symptom business Nuclear medicine Research Article |
| Zdroj: | Radiology and Oncology Radiology and oncology (Ljubljana) |
| ISSN: | 1581-3207 |
| Popis: | Background. The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of 99mTc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL. Materials and methods. The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis. Results. We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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