Biological screening and assessment of certain substituted monoazo heterocycles containing sulphur and / or nitrogen and their seleno like moieties
| Autor: | Mohamed E. Khalifa, Adel A. Gobouri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
thiophene
010405 organic chemistry General Chemical Engineering chemistry.chemical_element Industrial chemistry General Chemistry 010402 general chemistry 01 natural sciences Nitrogen Sulfur antitumor agents 0104 chemical sciences chemistry.chemical_compound Chemistry chemistry antioxidant activities Thiophene Organic chemistry selenium QD1-999 Selenium pathogenic microorganisms Biotechnology |
| Zdroj: | Polish Journal of Chemical Technology, Vol 19, Iss 4, Pp 28-35 (2017) |
| ISSN: | 1899-4741 |
| Popis: | The monoazo substituted five membered heterocycles, along with their seleno like moieties are still of interest in organic chemistry due to their medicinal and valuable applications. In continuation of our interest in the study of heterocyclic azo compounds containing sulphur and / or nitrogen heteroatoms, the synthesis of 5-aryl mono azo-thiazol-2-ylcarbamoyl-thiophene along with their seleno like derivatives of pyridine, pyridazine and quinolone, were accomplished. All the synthesized compounds were in vitro screening of their antioxidant activity, antitumor activity against Ehrlich ascites carcinoma cell EACC cell line and antimicrobial activity against various pathogenic microorganisms, such as Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and fungi strains of Aspergillus flavus and Candida albicans. The structural–activity relationship was studied based on the obtained data. |
| Databáze: | OpenAIRE |
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