In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit
| Autor: | Muhammad Rafique, Sheeba Ghani, Abubakar Shahid, Misbah Masood, Rehana Sharif, Ayesha Ashraf, Munir Ahmad, Dalaver H. Anjum |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Biodistribution Silver Materials science Metal Nanoparticles Nanoparticle Spleen Nanotechnology Silver nanoparticle chemistry.chemical_compound In vivo Materials Testing medicine Animals Tissue Distribution Particle Size Electrical and Electronic Engineering medicine.disease Electronic Optical and Magnetic Materials medicine.anatomical_structure Dextran Liver chemistry Organ Specificity Injections Intravenous Nanomedicine Rabbits Liver cancer Biotechnology Nuclear chemistry |
| Zdroj: | IET Nanobiotechnology. 9:368-374 |
| ISSN: | 1751-875X 1751-8741 |
| DOI: | 10.1049/iet-nbt.2014.0075 |
| Popis: | Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with (99m)Tc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that (99m)Tc-AgNPs and (99m)Tc-dextran-AgNPs are mainly accumulated in liver/spleen region but (99m)Tc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. |
| Databáze: | OpenAIRE |
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