Antinociceptive and anti-inflammatory properties of 7-epiclusianone, a prenylated benzophenone from Garcinia brasiliensis
| Autor: | Cláudia Quintino da Rocha, Fabiana C. Vilela, Maria Eliza de Castro Moreira, Flávia V. Santa-Cecília, Clarice de Carvalho Veloso, Marcelo Henrique dos Santos, Alexandre Giusti-Paiva, Lissara A.S. Freitas, Danielle Ferreira Dias |
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| Rok vydání: | 2011 |
| Předmět: |
Lipopolysaccharides
Male Hot Temperature medicine.drug_class medicine.medical_treatment Intraperitoneal injection Anti-Inflammatory Agents Pharmacology Peritonitis Carrageenan Anti-inflammatory chemistry.chemical_compound Benzophenones Mice medicine Benzoquinones Animals Edema Hot plate test Garcinia Acetic Acid Pain Measurement Antinociceptive Prenylation Analgesics biology Behavior Animal Clusiaceae 7-Epiclusianone biology.organism_classification Rats Nociception chemistry Biochemistry Garcinia brasiliensis Licking |
| Zdroj: | European journal of pharmacology. 670(1) |
| ISSN: | 1879-0712 |
| Popis: | 7-Epiclusianone, a natural prenylated benzophenone, was extracted from Garcinia brasiliensis Planch. & Triana (Clusiaceae), a native plant commonly known as bacupari and used in traditional Brazilian medicine for the treatment of inflammatory diseases. As a result of the wide spectrum of biological activities attributed to polyisoprenylated benzophenones, the aim of this study was to evaluate the analgesic and anti-inflammatory effects of 7-epiclusianone using two animal models. Carrageenan-induced paw oedema and peritonitis were used to investigate the anti-inflammatory activity of 7-epiclusianone in rats. The acetic acid-induced writhing, formalin and hot-plate tests were used to investigate its antinociceptive activity in mice. At test doses of 5, 10 and 15mg/kg p.o., 7-epiclusianone had an anti-inflammatory effect as demonstrated by the reduction of paw oedema induced by carrageenan and the inhibition of leukocyte recruitment into the peritoneal cavity. At the same doses, 7-epiclusianone inhibited nociception induced by an intraperitoneal injection of acetic acid, observed by the decrease in the number of writhing episodes. Additionally, 7-epiclusianone decreased licking time caused by a subplantar injection of formalin. Moreover, the hot plate test produced a significant increase in latency reaction, demonstrating an antinociceptive effect. The experimental data demonstrated that the polyisoprenylated benzophenone 7-epiclusianone has remarkable anti-inflammatory and antinociceptive activities. |
| Databáze: | OpenAIRE |
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