Induction of hepatic peroxisomes by a new, non-carboxylate-containing drug, bifonazole
| Autor: | Suga Tetsuya, Horie Shuichi, Fukumori Nobutaka |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Antifungal Agents Bifonazole Peroxisome Proliferation Biology Toxicology Microbodies medicine Animals Carnitine Clotrimazole Carnitine O-Acetyltransferase Carnitine O-Palmitoyltransferase Imidazoles Rats Inbred Strains General Medicine Organ Size Peroxisome Catalase Rats Biochemistry Mechanism of action Liver Acyltransferase Toxicity medicine.symptom Oxidation-Reduction medicine.drug |
| Zdroj: | Toxicology letters. 55(3) |
| ISSN: | 0378-4274 |
| Popis: | The acute effect of an antimycotic drug, bifonazole, on hepatic peroxisomes of rats was studied in comparison with that of clotrimazole, which has a similar structure. By feeding 0.5% bifonazole in the diet for 5 days, the activities of camitine acyltransferase, carnitine palmitoyltransferase and the peroxisomal β-oxidation system were increased by 30-, 3- and 7-fold, respectively, over the control. Under the same conditions, clotrimazole did not cause such changes. Electron microscopic observation showed that peroxisome proliferation had been induced by bifonazole treatment. Thus, a compound which does not contain a carboxylate moiety can induce peroxisomes in rodent liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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