Reduction of the Number of Major Representative Allergens: From Clinical Testing to 3-Dimensional Structures
| Autor: | Xueting Liu, He Lai, Huifang Chen, Zehong Zou, Ailin Tao, Ying He, Yuyi Huang, Junyan Zhang, Qiu-Rong Wu, Jianguo Zhang, Baoqing Sun, Shan Wang, Lida Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Allergy
China Article Subject Immunology Molecular Conformation Immunoglobulin E medicine.disease_cause Data sequences Allergen immune system diseases Allergy and Immunology lcsh:Pathology Mite medicine Hypersensitivity otorhinolaryngologic diseases Animals Humans Phylogeny Likelihood Functions Mites biology Allergen testing Intradermal testing Dust Cell Biology Allergens respiratory system biology.organism_classification medicine.disease respiratory tract diseases Southern china biology.protein Immunotherapy Peptides lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2014 (2014) |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/2014/291618 |
| Popis: | Vast amounts of allergen sequence data have been accumulated, thus complicating the identification of specific allergenic proteins when performing diagnostic allergy tests and immunotherapy. This study aims to rank the importance/potency of the allergens so as to logically reduce the number of allergens and/or allergenic sources. Meta-analysis of 62 allergenic sources used for intradermal testing on 3,335 allergic patients demonstrated that in southern China, mite, sesame, spiny amaranth,Pseudomonas aeruginosa, and house dust account for 88.0% to 100% of the observed positive reactions to the 62 types of allergenic sources tested. TheKolmogorov-SmironovTest results of the website-obtained allergen data and allergen family featured peptides suggested that allergen research in laboratories worldwide has been conducted in parallel on many of the same species. The major allergens were reduced to 21 representative allergens, which were further divided into seven structural classes, each of which contains similar structural components. This study therefore has condensed numerous allergenic sources and major allergens into fewer major representative ones, thus allowing for the use of a smaller number of allergens when conducting comprehensive allergen testing and immunotherapy treatments. |
| Databáze: | OpenAIRE |
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