18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons
| Autor: | Jeffrey L. Gunter, Matthew L. Senjem, David S. Knopman, Val J. Lowe, Stephen D. Weigand, Michelle M. Mielke, Bradley F. Boeve, Heather J. Wiste, Clifford R. Jack, Rosebud O. Roberts, Ronald C. Petersen, Emily S. Lundt, Kejal Kantarci, Prashanthi Vemuri |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Pathology Aging Fluorine Radioisotopes Heterozygote Genotype Glucose uptake Apolipoprotein E4 Precuneus FDG-Positron Emission Tomography Article Alzheimer Disease Fluorodeoxyglucose F18 Internal medicine medicine Dementia Humans Cognitive Dysfunction Alleles Aged Aged 80 and over medicine.diagnostic_test General Neuroscience Brain Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Glucose Positron emission tomography Posterior cingulate Positron-Emission Tomography Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Radiopharmaceuticals Psychology Developmental Biology |
| Popis: | Our objective was to examine associations between glucose metabolism, as measured by 18 F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E ( APOE ) e4 allele on glucose metabolism and on the associations between glucose metabolism and age. We studied 806 cognitively normal (CN) and 70 amyloid-imaging-positive cognitively impaired participants (35 with mild cognitive impairment and 35 with Alzheimer's disease [AD] dementia) from the Mayo Clinic Study of Aging, Mayo Alzheimer's Disease Research Center and an ancillary study who had undergone structural MRI, FDG PET, and 11 C-Pittsburgh compound B (PiB) PET. Using partial volume corrected and uncorrected FDG PET glucose uptake ratios, we evaluated associations of regional FDG ratios with age and carriage of an APOE e4 allele in CN participants between the ages of 30 and 95 years, and compared those findings with the cognitively impaired participants. In region-of-interest (ROI) analyses, we found modest but statistically significant declines in FDG ratio in most cortical and subcortical regions as a function of age. We also found a main effect of APOE e4 genotype on FDG ratio, with greater uptake in e4 noncarriers compared with carriers but only in the posterior cingulate and/or precuneus, lateral parietal, and AD-signature meta-ROI. The latter consisted of voxels from posterior cingulate and/or precuneus, lateral parietal, and inferior temporal. In age- and sex-matched CN participants the magnitude of the difference in partial volume corrected FDG ratio in the AD-signature meta-ROI for APOE e4 carriers compared with noncarriers was about 4 times smaller than the magnitude of the difference between age- and sex-matched elderly APOE e4 carrier CN compared with AD dementia participants. In an analysis in participants older than 70 years (31.3% of whom had elevated PiB), there was no interaction between PiB status and APOE e4 genotype with respect to glucose metabolism. Glucose metabolism declines with age in many brain regions. Carriage of an APOE e4 allele was associated with reductions in FDG ratio in the posterior cingulate and/or precuneus, lateral parietal, and AD-signature ROIs, and there was no interaction between age and APOE e4 status. The posterior cingulate and/or precuneus and lateral parietal regions have a unique vulnerability to reductions in glucose metabolic rate as a function both of age and carriage of an APOE e4 allele. |
| Databáze: | OpenAIRE |
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