Effects of tityustoxin on cerebral inflammatory response in young rats
Autor: | Ricardo Nascimento Araújo, Patrícia Alves Maia Guidine, Rosa Maria Esteves Arantes, Iva Tereza Van Fraga, Tasso Moraes-Santos, André R. Massensini, Marcelo Limborço-Filho, Juliana Carvalho-Tavares, Márcio Flávio Dutra Moraes, Onésia Cristina Oliveira Lima, Norinne Lacerda-Queiroz |
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Rok vydání: | 2015 |
Předmět: |
Male
Scorpion envenoming Tityus serrulatus Brain inflammation Neuroscience(all) Inflammatory response Neurotoxins Scorpion Venoms Venom Leukocyte Rolling Scorpion stings Pharmacology Microcirculation Tityustoxin chemistry.chemical_compound TsTX Leukocyte Trafficking Cell Adhesion Leukocytes Animals Medicine Rats Wistar Scorpion Stings biology Tumor Necrosis Factor-alpha business.industry General Neuroscience Leukocyte trafficking Brain biology.organism_classification medicine.disease chemistry Microvessels Immunology Encephalitis business |
Zdroj: | Neuroscience Letters. 588:24-28 |
ISSN: | 0304-3940 |
Popis: | Accidents caused by scorpion stings, mainly affecting children, are considered an important cause of morbidity and mortality in tropical countries. Clinical studies demonstrate the relevant role of systemic inflammatory events in scorpion envenoming. However, remains poorly understood whether the major lethal component in Tityus serrulatus venom, tityustoxin (TsTX), is able to induce inflammatory responses in the cerebral microcirculation. In this study, we systematically examined leukocyte recruitment into the CNS in response to TsTX injection. Accordingly, developing rats were subjected to a subcutaneous (s.c.) injection of TsTX (0.75 mg/kg), and leukocyte recruitment (i.e., 4, 8 and 12 h after injection) and TNF-α levels were evaluated. Rats injected with TsTX presented a significant increase in leukocyte rolling and adhesion and higher levels of TNF-α at all time points studied, compared to the control group. Altogether, this work demonstrates the triggering of neuroimmunological mechanisms induced by TsTX injection in young rats. |
Databáze: | OpenAIRE |
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