Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms
| Autor: | Priska Stahel, Gary F. Lewis, Changting Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
SMC smooth muscle cell Review Energy homeostasis 0302 clinical medicine Chylomicrons apo apolipoprotein GLP-2 glucagon-like peptide-2 TG triglyceride Chemistry Gastroenterology eNOS endothelial nitric oxide synthase VEGF-C vascular endothelial growth factor C MTP microsomal triglyceride transfer protein mRNA messenger RNA 3. Good health Cell biology Intestine Plin perilipin medicine.anatomical_structure PCTV prechylomicron transport vesicle VEGFR vascular endothelial growth factor receptor CLD cytoplasmic lipid droplet vSNARE vesicle soluble NSF attachment protein receptor Lymphatics 030211 gastroenterology & hepatology Lymph Intracellular SNARE soluble NSF attachment protein receptor Enterocyte CRL Calcitonin receptor-like receptor Chylomicron ER endoplasmic reticulum 03 medical and health sciences medicine Animals Humans Secretion lcsh:RC799-869 Triglycerides SDR39U1 short-chain dehydrogenase/reductase family 39U member 1 Lamina propria NO nitric oxide ENS enteric nervous system Mucous Membrane Hepatology FA fatty acid VLDL very-low-density lipoprotein Biological Transport STXBP5 syntaxin-binding protein 5 FABP fatty acid binding protein Lipid Metabolism Dietary Fats CM chylomicron 030104 developmental biology MG monoglyceride GLP-2R glucagon-like peptide-2 receptor LCFA long-chain fatty acid lcsh:Diseases of the digestive system. Gastroenterology Lipoprotein Hormone |
| Zdroj: | Cellular and Molecular Gastroenterology and Hepatology Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 487-501 (2019) |
| ISSN: | 2352-345X |
| Popis: | Rapid and efficient digestion and absorption of dietary triglycerides and other lipids by the intestine, the packaging of those lipids into lipoprotein chylomicron (CM) particles, and their secretion via the lymphatic duct into the blood circulation are essential in maintaining whole-body lipid and energy homeostasis. Biosynthesis and assembly of CMs in enterocytes is a complex multistep process that is subject to regulation by intracellular signaling pathways as well as by hormones, nutrients, and neural factors extrinsic to the enterocyte. Dysregulation of this process has implications for health and disease, contributing to dyslipidemia and a potentially increased risk of atherosclerotic cardiovascular disease. There is increasing recognition that, besides intracellular regulation of CM assembly and secretion, regulation of postassembly pathways also plays important roles in CM secretion. This review examines recent advances in our understanding of the regulation of CM secretion in relation to mobilization of intestinal lipid stores, drawing particular attention to post-assembly regulatory mechanisms, including intracellular trafficking of triglycerides in enterocytes, CM mobilization from the lamina propria, and regulated transport of CM by intestinal lymphatics. Keywords: Intestine, Chylomicron, Triglycerides, Lymphatics |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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