Hippocampal dysfunction defines disease onset in Huntington's disease
| Autor: | Sarah L Mason, Roger A. Barker, Faye Begeti, Laetitia C Schwab |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Morris water navigation task Hippocampus Disease Neuropsychological Tests Hippocampal formation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Huntington's disease medicine Humans Cambridge Neuropsychological Test Automated Battery Case-control study Cognition Middle Aged medicine.disease Psychiatry and Mental health Huntington Disease 030104 developmental biology Case-Control Studies Disease Progression Surgery Neurology (clinical) Cognition Disorders Psychology Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 87:975-981 |
| ISSN: | 1468-330X 0022-3050 |
| DOI: | 10.1136/jnnp-2015-312413 |
| Popis: | Background Huntington9s disease (HD) is an autosomal dominant neurodegenerative disorder characterised by a triad of motor, psychiatric and cognitive deficits with the latter classically attributed to disruption of frontostriatal networks. However, emerging evidence from animal models of HD suggests that some of the early cognitive deficits may have a hippocampal basis. The objective of this study was to link previous rodent findings in this area to clinical practice. Methods In this study, 94 participants included patients with early HD, premanifest HD and age-matched controls underwent hippocampal-based cognitive assessments. These included a virtual reality version of the Morris water maze, a task involved participants having to swim through a virtual pool to find a submerged platform using a joystick, and the Cambridge Neuropsychological Test Automated Battery (CANTAB) paired associates learning task, a test also known to rely on hippocampal integrity. Results Patients with early HD showed impaired performance in both the virtual Morris water maze and the CANTAB paired associates learning. Such deficits were also correlated with estimated years to diagnosis in premanifest participants. Conclusions This study highlights the merit of using analogous tests in the laboratory and clinic and demonstrates that hippocampal impairments are an early feature of HD in patients as previously shown in rodent models of the disease. As such, they could be used not only to assist in the diagnosis of disease onset, but may also be useful as an outcome measure in future therapeutic trials. |
| Databáze: | OpenAIRE |
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