Obesity Is Associated with Increased Risk of Colectomy in Inflammatory Bowel Disease Patients Hospitalized with Clostridium difficile Infection
| Autor: | Manish P. Shrestha, Sasha Taleban |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Databases Factual genetic structures Physiology medicine.medical_treatment Logistic regression Risk Assessment Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology Prevalence medicine Humans Hospital Mortality Obesity Colectomy Aged Inpatients business.industry Incidence Gastroenterology Odds ratio Middle Aged Clostridium difficile Hepatology Inflammatory Bowel Diseases medicine.disease United States digestive system diseases Hospitalization Treatment Outcome 030220 oncology & carcinogenesis Clostridium Infections Female 030211 gastroenterology & hepatology business |
| Zdroj: | Digestive Diseases and Sciences. 64:1632-1639 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-018-5423-7 |
| Popis: | Obesity and inflammatory bowel disease (IBD) are associated with increased risk of Clostridium difficile infection (CDI). The effect of obesity on IBD course and development of complications is poorly understood. We performed this study to examine the effect of obesity on CDI-related morbidity and mortality in hospitalized patients with IBD. We used data from the National Inpatient Sample across five study years (2010–2014) to identify patients ≥ 18 years hospitalized with both CDI and IBD. We compared the outcomes of in-hospital mortality, partial or total colectomy, hospital length of stay, and hospital charges between obese and non-obese IBD–CDI patients. Analysis included univariate and multivariate linear and logistic regression analyses. Of 304,298 hospitalized patients with IBD, 13,517 (4.4%) patients had CDI. Of these, 996 (7.4%) patients were obese. Obese IBD–CDI patients had a higher risk of colectomy (adjusted odds ratio, AOR 1.60, 95% CI 1.30–1.96; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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