Effect of nonselective beta-adrenoblockers on the state of sympathoadrenal system and ratio of neuroactive amino acids in rat medulla oblongata
| Autor: | D. R. Tatulashvili, M. I. Kiguradze, P. A. Galenko-Yaroshevskii, A. V. Uvarov, A. Yu. Turovaya, G. V. Sukoyan, A. Kh. Kade |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Sympathetic Nervous System Adrenergic beta-Antagonists Propranolol General Biochemistry Genetics and Molecular Biology Norepinephrine Random Allocation Catecholamines Dopamine Internal medicine Adrenal Glands medicine Sympathoadrenal system Animals Amino Acids gamma-Aminobutyric Acid chemistry.chemical_classification Medulla Oblongata General Medicine Amino acid Rats Endocrinology Epinephrine chemistry Medulla oblongata Excitatory postsynaptic potential medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 139(5) |
| ISSN: | 0007-4888 |
| Popis: | Experiments on rats showed that injection of propranolol into the medulla oblongata increased the contents of epinephrine, norepinephrine, dopamine, and L-DOPA by 3.76, 1.4, 2.0, and 1.7 times, respectively. These propranolol-induced changes in the levels and ratio of neuro-transmitters were not accompanied by variations in serotonin content. Propranolol had no significant effects on the content of excitatory amino acids, except marked increase in aspartate content. The level of inhibitory amino acids increased mainly due to an increase in GABA content. The balance between excitatory and inhibitory amino acids was shifted towards inhibitory compounds. |
| Databáze: | OpenAIRE |
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