| Autor: |
Jonathan Reboulet, Rachel E. Paul, Marilyne Duffraisse, Ingrid Lohmann, Samir Merabet, Julie Carnesecchi, Leiore Ajuria, Agnes Banretti, Bruno Hudry |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| DOI: |
10.1101/843383 |
| Popis: |
Hox proteins are major regulators of embryonic development, acting in the nucleus to regulate the expression of their numerous downstream target genes. By analyzing deleted forms of theDrosophilaHox protein Ultrabithorax (Ubx), we revealed the presence of an unconventional Nuclear Export Signal (NES) that overlaps with the highly conserved hexapeptide (HX) motif. This short linear motif was originally described as mediating the interaction with the PBC proteins, a generic and crucial class of Hox transcriptional cofactors in development and cancer. Here we show that the HX motif is involved in the interaction with the major CRM1/Embargoed exportin protein. This novel role was found in severalDrosophilaand human Hox proteins. We provide evidence that HX-dependent Hox nuclear export is tightly regulated in theDrosophilafat body to control the onset of autophagy. Our results underline the high molecular versatility of a unique short peptide motif for controlling context-dependent activity of Hox proteins at both transcriptional and non-transcriptional levels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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