Brief Report: Increased Cotinine Concentrations are Associated With Reduced Expression of Cathelicidin (LL-37) and NOD-2 in Alveolar Macrophages of PLWH Who Smoke
| Autor: | Anasuya Sarkar, Mikhail A. Gavrilin, Kristine K. Browning, Mark D. Wewers, Teresa Trinka, Jennifer L. Hollyfield, Philip T. Diaz, Mary Ellen Wewers, Amy K. Ferketich |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_treatment Population Nod2 Signaling Adaptor Protein HIV Infections 030312 virology Real-Time Polymerase Chain Reaction Article Cathelicidin Nicotine 03 medical and health sciences chemistry.chemical_compound Immune system Cathelicidins Macrophages Alveolar medicine Humans Pharmacology (medical) Prospective Studies Cotinine Saliva education 0303 health sciences education.field_of_study Innate immune system medicine.diagnostic_test business.industry Smoking Infectious Diseases Bronchoalveolar lavage chemistry Immunology Alveolar macrophage Female business Antimicrobial Cationic Peptides medicine.drug |
| Zdroj: | J Acquir Immune Defic Syndr |
| ISSN: | 1525-4135 |
| Popis: | There is a strong link between cigarette smoking and pulmonary complications among people living with HIV. However, the effects of smoking on the local lung immune environment in this population remain unclear. Bronchoalveolar lavage and saliva were collected from HIV-infected smokers involved in a prospective study investigating alveolar macrophage expression of host defense molecules. Salivary cotinine concentrations were inversely related to expression of the immune cell receptor nucleotide-binding oligomerization domain-2 and the cathelicidin antimicrobial peptide LL-37. The negative correlation between salivary cotinine and LL-37 was particularly strong. Our study provides insight into how nicotine may adversely affect lung innate immunity in HIV. |
| Databáze: | OpenAIRE |
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