Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population
| Autor: | G. Srinivasa Nageswara Rao, R. Sai Babu, Prema Gurumurthy, Dolice Victor, K.M. Cherian, Arumugam Sarasa Bharati, Priya Gururajan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Acute coronary syndrome Genotype Nitric Oxide Synthase Type III India Enzyme-Linked Immunosorbent Assay Nitric Oxide Biochemistry Polymerase Chain Reaction Nitric oxide law.invention chemistry.chemical_compound Plasma Gene Frequency law Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Acute Coronary Syndrome Molecular Biology Allele frequency Ecology Evolution Behavior and Systematics Polymerase chain reaction Polymorphism Genetic biology General Medicine Middle Aged medicine.disease Introns Genotype frequency Nitric oxide synthase Endocrinology chemistry Tandem Repeat Sequences biology.protein Gene polymorphism |
| Zdroj: | Biochemical genetics. 49(1-2) |
| ISSN: | 1573-4927 |
| Popis: | In an analysis of the possible association of endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and plasma nitric oxide levels in patients with acute coronary syndrome, we investigated 106 patients with the syndrome and 100 healthy controls. Genotype was determined using the polymerase chain reaction; plasma nitric oxide levels were found using ELISA. The genotype frequencies for the a/b polymorphism in the control group were 77% for bb, 19% for ab, and 4% for aa. In the patients, genotype frequencies were 55% bb, 34% ab, and 11% aa. The allele frequencies were 28% a and 72% b among the patients and 13% a and 87% b among control subjects. Our findings showed a significant association of the ecNOS gene polymorphism with acute coronary syndrome in the South Indian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink