Expression of the Epidermodysplasia Verruciformis-Associated Genes EVER1 and EVER2 Is Activated by Exogenous DNA and Inhibited by LMP1 Oncoprotein from Epstein-Barr Virus
| Autor: | C. Cohen, Djamel Saidj, Ivonne Rubio, Patrick van Uden, Maha Siouda, Rosita Accardi, Massimo Tommasino, Patrick Lomonte, Cecilia Frecha, Sébastien A. Chevalier |
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| Přispěvatelé: | Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Institut NeuroMyoGène (INMG), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Herpesvirus 4
Human EBV-LMP1 Immunology education EVER1 EVER2 Biology medicine.disease_cause Microbiology Virus Viral Matrix Proteins Ciencias Biológicas Virology medicine Humans Gene ComputingMilieux_MISCELLANEOUS Regulation of gene expression B-Lymphocytes Viral matrix protein Membrane Proteins Epidermodysplasia verruciformis medicine.disease Epstein–Barr virus 3. Good health Virus-Cell Interactions Gene Expression Regulation Insect Science Epidermodysplasia Verruciformis Host-Pathogen Interactions [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Ectopic expression Signal transduction Virología CIENCIAS NATURALES Y EXACTAS BCELLS |
| Zdroj: | Journal of Virology Journal of Virology, American Society for Microbiology, 2015, 89 (2), pp.1461-1467. ⟨10.1128/JVI.02936-14⟩ |
| ISSN: | 0022-538X 1098-5514 |
| Popis: | EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells. Fil: Frecha, Cecilia Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. International Agency For Research On Cancer; Francia Fil: Chevalier, Sébastien A.. International Agency For Research On Cancer; Francia Fil: van Uden, Patrick. International Agency For Research On Cancer; Francia Fil: Rubio, Ivonne. International Agency For Research On Cancer; Francia Fil: Siouda, Maha. International Agency For Research On Cancer; Francia Fil: Saidj, Djamel. International Agency For Research On Cancer; Francia Fil: Cohen, Camille. Université Claude Bernard Lyon 1; Francia. Centre National de la Recherche Scientifique; Francia Fil: Lomonte, Patrick. Centre National de la Recherche Scientifique; Francia. Université Claude Bernard Lyon 1; Francia Fil: Accardi, Rosita. International Agency For Research On Cancer; Francia Fil: Tommasino, Massimo. International Agency For Research On Cancer; Francia |
| Databáze: | OpenAIRE |
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