Association between pre/perinatal exposure to POPs and children's anogenital distance at age 4 years: A study from the INMA-Asturias cohort
| Autor: | Carmen Freire, Joan O. Grimalt, Adonina Tardón, Ana Cristina Rodríguez-Dehli, Ana Fernández-Somoano, Esther Vizcaino, Miguel García-Villarino, Isolina Riaño-Galán |
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| Přispěvatelé: | Grimalt, Joan O., Grimalt, Joan O. [0000-0002-7391-5768] |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Anal Canal Endocrine Disruptors 010501 environmental sciences 01 natural sciences Cohort Studies Anogenital index chemistry.chemical_compound 0302 clinical medicine Pregnancy Halogenated Diphenyl Ethers Hydrocarbons Chlorinated Medicine 030212 general & internal medicine Maternal-Fetal Exchange Anthropometry Perinatal Exposure Obstetrics Persistent organic pollutants Anogenital distance Fetal Blood Endocrine disruptor Maternal Exposure Child Preschool Prenatal Exposure Delayed Effects Cohort Environmental Pollutants Female Biological Monitoring Adult medicine.medical_specialty 03 medical and health sciences Humans Sex organ Genitalia Persistent organic pollutant 0105 earth and related environmental sciences business.industry Infant Newborn Public Health Environmental and Occupational Health Hexachlorobenzene Confidence interval Genital development chemistry Spain business |
| Zdroj: | Scopus RUO. Repositorio Institucional de la Universidad de Oviedo Universidad de las Islas Baleares Digital.CSIC. Repositorio Institucional del CSIC instname RUO: Repositorio Institucional de la Universidad de Oviedo Universidad de Oviedo (UNIOVI) |
| Popis: | Background Prenatal exposure to endocrine-disrupting chemicals may impair genital development and alter reproductive tract anatomy. Anogenital distance (AGD) is a useful biomarker of exposure to chemicals that act as endocrine disruptors. We evaluated associations between prenatal and perinatal exposure to several persistent organic pollutants (POPs) and AGD in 4-year-old children. Methods Data were drawn from the INMA-Asturias cohort. Pediatricians measured the anofourchetal distance in female children and anoscrotal distance in male children. The anogenital index (AGI) was defined as the AGD divided by the child's weight at age of examination. We measured the levels of two hexachlorocyclohexane isomers, hexachlorobenzene, dichlorodiphenyltrichloroethane (DDT) and its metabolites, six polychlorinated biphenyl (PCB) congeners, and six polybrominated diphenyl ether (PBDE) congeners in maternal serum at 12 gestational weeks (n = 155) and in cord blood serum (n = 229). Anthropometric and parental sociodemographic variables were collected via face-to-face interviews. Linear regression models were used to evaluate the relationship between exposure to POPs and AGI, adjusted for confounders and stratified by sex. Results In male children, we found inverse associations between AGI and maternal concentrations of PCB-138 (ß = −0.041, 95% confidence interval [CI]: −0.074, −0.008, second tertile), PCB-153 (ß = −0.052, 95% CI: −0.085, −0.020, second tertile), PCB-180 ß = −0.065, 95% CI: −0.096, −0.035, second tertile; ß = −0.042, 95% CI: −0.073, −0.011, third tertile), PBDE-209 (ß = −0.031, 95% CI: −0.058, −0.006), cord serum concentrations of PCB-153 (ß = −0.029, 95% CI: −0.059, −0.000, second tertile; ß = −0.047, 95% CI: −0.085, −0.008, third tertile), and PCB-180 (ß = −0.041, 95% CI: −0.078, −0.005, third tertile). In female children, AGI was positively associated with maternal serum concentrations of PCB-101 (ß = 0.039, 95% CI: 0.002, 0.076, second tertile), and higher cord serum levels of 4,4′-DDT (ß = 0.032, 95% CI: 0.003, 0.061, third tertile) and 4,4′-DDE (ß = 0.040, 95% CI: 0.011, 0.069, third tertile). Conclusions Our findings provide evidence of associations between specific POPs and AGI in boys and girls aged 4 years, and suggest that pre/perinatal exposure to POPs has a feminizing effect in males and a masculinizing effect in females. The authors would particularly like to thank all the participants for their generous collaboration and the staff from Hospital San Agustin in Aviles for their effort. This study was funded by grants from, CIBERESP (PhD-employment-contract and fellowship for short stays abroad-2019), FIS-FEDER: PI04/2018, PI09/02311, PI13/02429, PI18/00909; Obra Social Cajastur/Fundación Liberbank, and Universidad de Oviedo. We thank Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript, and Fundación NOE Alimerka. |
| Databáze: | OpenAIRE |
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