Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activities from Mamuyo (Styrax ramirezii Greenm.) Fruit
| Autor: | Michael Timmers, Mary Ann Lila, Debora Esposito, Octavio Paredes-López, Jorge L. Guerrero-Medina, Mary H. Grace, Pedro A. García-Saucedo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Antioxidant
Lipopolysaccharide medicine.drug_class medicine.medical_treatment Interleukin-1beta Anti-Inflammatory Agents Nitric Oxide Synthase Type II Inflammation Nitric Oxide Antioxidants Styrax Anti-inflammatory Nitric oxide chemistry.chemical_compound Phenols medicine Humans chemistry.chemical_classification Reactive oxygen species biology Traditional medicine Plant Extracts General Chemistry Nitric oxide synthase Styrax ramirezii chemistry Biochemistry Cyclooxygenase 2 Fruit biology.protein medicine.symptom Reactive Oxygen Species General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 63:10459-10465 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.5b04781 |
| Popis: | Extracts of Styrax ramirezii Greenm., a fruit traditionally valued for health and wellness in Mexico, were analyzed phytochemically and evaluated for antioxidant and anti-inflammatory activity. Six norneolignans were identified by HPLC-TOF-MS, and the two major compounds were isolated for further evaluation. The effects of the isolated norneolignans, egonol and homoegonol, on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, reactive oxygen species (ROS) production, and biomarkers of inflammation were evaluated. Of the tested compounds, egonol potently inhibited the production of NO and also significantly reduced the release of ROS. Consistent with these observations, the mRNA expression levels of inducible nitric oxide synthase (iNOS) (0.668 ± 0.108), cyclooxygenase-2 (COX-2) (0.553 ± 0.007), interleukin-1β (IL-1β) (0.093 ± 0.005), and interleukin-6 (IL-6) (0.298 ± 0.076) were reduced by egonol. The activity for both egonol and homoegonol increased in a concentration-dependent manner. These results suggest the potential of S. ramirezii Greenm. fruit to contribute to a healthy diet, rich in antioxidant and anti-inflammatory compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|