Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters
| Autor: | M. Rosa Boleda, Encarnación Moyano, Élida Alechaga, M. Teresa Galceran, Francesc Ventura |
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| Rok vydání: | 2014 |
| Předmět: |
Sulfamethoxazole
Health Toxicology and Mutagenesis Erythromycin Ibuprofen Azithromycin Tandem mass spectrometry Mass spectrometry Tandem Mass Spectrometry Clarithromycin medicine Environmental Chemistry Chromatography Chemistry Drinking Water General Medicine Pollution Triple quadrupole mass spectrometer Pharmaceutical Preparations Spain Water Pollutants Chemical medicine.drug Chromatography Liquid Environmental Monitoring |
| Zdroj: | Environmental science and pollution research international. 21(18) |
| ISSN: | 1614-7499 |
| Popis: | Fifty samples of finished drinking waters (FDWs) from Spain covering 12 million inhabitants were tested for 53 pharmaceuticals pertaining to 12 different Anatomical Therapeutic Chemical (ATC) classification system codes. The studied compounds are a combination of most commonly consumed pharmaceuticals with other barely reported in the literature. Five compounds, azithromycin, clarithromycin, erythromycin, sulfamethoxazole, and ibuprofen were tentatively identified by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in some samples (2 to 15 %), but only ibuprofen and azithromycin could be confirmed when analyzed by liquid chromatography–high-resolution mass spectrometry (LC-HRMS) with a quadrupole-Orbitrap instrument. Concentration levels of ibuprofen in the positive samples ranged from 12 to 17 ng/L (n = 6) while for azithromycin values from 5 to 9.5 ng/L (n = 3) were found. Ibuprofen fragmentation behaviour in different mass spectrometry instrument configurations (triple quadrupole, quadrupole-ion trap, and quadrupole-Orbitrap) was evaluated. |
| Databáze: | OpenAIRE |
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