The SL autoantibody-antigen system: clinical and biochemical studies
| Autor: | Grv Hughes, R C Gainey, S. H. Morgan, C C Bunn, Michael B. Mathews, Robert M. Bernstein |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Anti-nuclear antibody
Immunology Human leukocyte antigen General Biochemistry Genetics and Molecular Biology Autoimmune Diseases Rheumatology Antigen medicine Chemical Precipitation Humans Lupus Erythematosus Systemic Immunology and Allergy Immunoelectrophoresis Autoantibodies Autoimmune disease biology business.industry Autoantibody medicine.disease Precipitin Molecular biology Peptide Fragments Antibodies Antinuclear biology.protein Electrophoresis Polyacrylamide Gel Antibody business Research Article Anti-SSA/Ro autoantibodies |
| Zdroj: | Annals of the Rheumatic Diseases. 45:353-358 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.45.5.353 |
| Popis: | A recently described autoantibody, SL, was found in serum from 27 patients with autoimmune disease, including 20 with systemic lupus erythematosus (SLE) where the frequently was 7%. Analysis of clinical, serological, and HLA data from 119 SLE patients showed no positive associations with anti-SL antibody apart from a higher frequency of non-infective fever. Most SL positive sera contained other precipitins, notably antibodies to Ro(SS-A) and the proliferating cell nuclear antigen, PCNA. Anti-SL IgG recognised a protein of 32 000 daltons without associated RNA. This polypeptide was distinguished from a similarly sized component of the Sm and RNP ribonucleoprotein particles by demonstrating different products of partial proteolysis. Although anti-SL antibody is of limited clinical importance, it occurs with twice the frequency of anti-SM antibody in white patients with SLE. Preliminary studies indicate that SL and the Japanese Ki system are identical. |
| Databáze: | OpenAIRE |
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