Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer
| Autor: | Rolf Lewensohn, Bo Nilsson, Axel Glaessgen, Sara Jonmarker, Alexander Valdman, Lars Egevad, Peter Ekman, Anna Lena Lindberg |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Microbiology (medical) Biochemical recurrence Oncology medicine.medical_specialty Pathology animal structures medicine.medical_treatment HSP27 Heat-Shock Proteins urologic and male genital diseases Disease-Free Survival Pathology and Forensic Medicine Prostate cancer Prostate Internal medicine Heat shock protein Biomarkers Tumor medicine Humans Immunology and Allergy HSP70 Heat-Shock Proteins Aged Prostatectomy Tissue microarray business.industry Prostatic Neoplasms Cancer Chaperonin 60 General Medicine Middle Aged Prostate-Specific Antigen Microarray Analysis Prognosis medicine.disease Immunohistochemistry Hsp70 medicine.anatomical_structure Neoplasm Recurrence Local business |
| Zdroj: | APMIS. 116:888-895 |
| ISSN: | 1600-0463 0903-4641 |
| DOI: | 10.1111/j.1600-0463.2008.01051.x |
| Popis: | Heat shock proteins (HSPs) protect cells against stress-associated injury and are overexpressed in several malignant tumors. We aimed to investigate their value as prognostic markers in prostate cancer. A tissue microarray (TMA) was constructed of 289 prostate cancers from radical prostatectomy (RP) specimens with median follow-up of 48.9 months. Slides were immunostained for HSP27, HSP60 and HSP70. Intensity and extent of immunoreactivity (IR) and their product (IRp) was evaluated by two observers. The IRp of HSP27 and HSP60, but not of HSP70, significantly predicted biochemical recurrence (p=0.014, 0.034 and 0.160, respectively). Recurrence-free survival in patients with strong HSP27 and HSP60 staining was shorter than in those with weak expression (p=0.019 and 0.001, respectively). IRp of HSP27 and HSP60 correlated with Gleason score (p |
| Databáze: | OpenAIRE |
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