Ractopamine residue in meat might protect people from Parkinson disease
| Autor: | Frank S Fan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Agonist medicine.medical_specialty Meat medicine.drug_class Swine Feed additive Population Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Phenethylamines Medicine Animals education education.field_of_study Lewy body business.industry Dopaminergic Antagonist Parkinson Disease General Medicine medicine.disease nervous system diseases Ractopamine 030104 developmental biology Endocrinology chemistry alpha-Synuclein Cattle Lewy Bodies business 030217 neurology & neurosurgery |
| Zdroj: | Medical hypotheses. 145 |
| ISSN: | 1532-2777 |
| Popis: | There is still no curative treatment for the exasperating Parkinson disease, the second most common neurodegenerative disorder. Intracytoplasmic Lewy body composing of phosphorylated α-synuclein in dopaminergic neuronal cells has been recognized as the characteristic pathologic change and believed to be the cause of neuronal cell loss in Parkinson disease. Recently, β-adrenoreceptor antagonist was found to be correlated with an increasing incidence of Parkinson disease and β-adrenoreceptor agonist, capable of inhibiting gene expression of α-synuclein, was associated with a reduced incidence of it. Therefore, a hypothesis is raised that ractopamine, a β-adrenoreceptor agonist used as feed additive for increasing leanness of finishing cattle and swine, might provide protective effects for Parkinson disease and lower its incidence in the population consuming meat containing ractopamine residue. |
| Databáze: | OpenAIRE |
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