Pharmacogenomic assessment of Mexican and Peruvian populations
| Autor: | Jane Y Revollo, Robert H. Gilman, Derek J. Van Booven, Cristi R. King, Sharon Marsh, Howard L. McLeod |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Genotype Population Pilot Projects Context (language use) Biology Polymorphism Single Nucleotide Article Gene Frequency Polymorphism (computer science) Peru Genetics Humans Allele education Mexico Allele frequency Alleles Pharmacology education.field_of_study Pharmacogenetics Pharmacogenomics Molecular Medicine Female |
| Zdroj: | Pharmacogenomics. 16:441-448 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs.15.10 |
| Popis: | Background: Clinically relevant polymorphisms often demonstrate population-specific allele frequencies. Central and South America remain largely uncategorized in the context of pharmacogenomics. Materials & methods: We assessed 15 polymorphisms from 12 genes (ABCB1 3435C>T, ABCG2 Q141K, CYP1B1*3, CYP2C19*2, CYP3A4*1B, CYP3A5*3C, ERCC1 N118N, ERCC2 K751Q, GSTP1 I105V, TPMT 238G>C, TPMT 460G>A, TPMT 719A>G, TYMS TSER, UGT1A1*28 and UGT1A1 -3156G>A) in 81 Peruvian and 95 Mexican individuals. Results: Six polymorphism frequencies differed significantly between the two populations: ABCB1 3435C>T, CYP1B1*3, GSTP1 I105V, TPMT 460G>A, UGT1A1*28 and UGT1A1 -3156G>A. The pattern of observed allele frequencies for all polymorphisms could not be accurately estimated from any single previously studied population. Conclusion: This highlights the need to expand the scope of geographic data for use in pharmacogenomics studies. |
| Databáze: | OpenAIRE |
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