Giant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge
| Autor: | Ana Paula Correia de Araújo Bezerra, Richard Louis Voegels, Fábio de Rezende Pinna, Marco Aurélio Fornazieri, Bruno Barros Pinto Borges, Leandro Aurelio Liporoni Martins |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Skull Neoplasms Parathyroid hormone Facial Bones Diagnosis Differential Granuloma Giant Cell Humans Immunology and Allergy Medicine Neoplastic transformation Giant Cell Tumors Craniofacial Child Aged Giant Cell Tumor of Bone Hyperparathyroidism business.industry Middle Aged medicine.disease Brown tumor Otorhinolaryngology Giant cell Female Differential diagnosis business |
| Zdroj: | International Forum of Allergy & Rhinology. 2:501-506 |
| ISSN: | 2042-6976 |
| DOI: | 10.1002/alr.21050 |
| Popis: | Background: Giant cell tumors of bone (GCTs) are common in the long bones, but rare in the craniofacial region, with only 1% of cases occurring in the latter. Clinical, radiological, and anatomical diagnosis of this locally aggressive disease, which occurs in response to trauma or neoplastic transformation, poses a major challenge in clinical practice. Methods: The present study describes a series of 4 cases and highlights the main features of the differential diagnosis and treatment of these lesions: GCT, giant cell reparative granuloma (GCRG), and the brown tumor of hyperparathyroidism. Results: GCT presents as a benign neoplasm, most typically affecting the knees, and rarely in the temporal and sphenoid bones. It is radiologically indistinguishable from GCRG due to its lytic, poorly defined appearance. The distinction can only be made microscopically, as the presence of multinucleated giant cells scattered throughout the stroma and the absence of a history of trauma favor a diagnosis of GCT. The brown tumor of hyperparathyroidism occurs with rapid, localized osteoclast activity secondary to the effects of increased parathyroid hormone (PTH) levels; parathyroid examination is indispensable. Conclusion: The diagnosis and treatment of these lesions poses a major challenge due to their similar clinical presentation and radiological appearance. Accurate diagnosis is essential for definition of appropriate management, as complete resection is the goal in GCT and GCRG to avoid recurrence, whereas the brown tumor often yields to treatment of the underlying hyperparathyroidism. |
| Databáze: | OpenAIRE |
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