Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma
| Autor: | Brenda F. Jones, John C. Merritt, Dwight D. Perry, David N. Russell |
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| Rok vydání: | 1981 |
| Předmět: |
Male
Time Factors genetic structures medicine.medical_treatment Ocular tension Glaucoma Blood Pressure Pharmacology Marihuanas Cannabis sativa Dogs Species Specificity mental disorders medicine Animals Humans Pharmacology (medical) Dronabinol Intraocular Pressure Corneal epithelium Aged Chemistry organic chemicals Middle Aged medicine.disease eye diseases medicine.anatomical_structure Blood pressure Anesthesia Female sense organs Cannabinoid Δ9-tetrahydrocannabinol Ophthalmic Solutions |
| Zdroj: | Journal of clinical pharmacology. 21(S1) |
| ISSN: | 0091-2700 |
| Popis: | Systemic delta 9-tetrahydrocannabinol (THC), administered either by smoking marihuana or as synthetic THC in soft gelatin capsules, lowers ocular tension in various glaucomas, but at the expense of significant decreases in systolic blood pressure. Topical THC in light mineral oil vehicles, though effective in laboratory animals, was not shown effective in 0.05 and 0.1% topical solutions when administered to six subjects with primary open-angle glaucoma in a randomized, balanced, double-masked protocol. Light mineral oil, which has an affinity for corneal epithelium, is an optimum vehicle for administering drugs whose mechanisms of action are systemic rather than local within the eye. Further glaucoma research should therefore proceed with marihuanas containing insignificant levels of THC (less than 0.4%) and with various local delivery systems of the ocular-active cannabinoid found in Cannabis sativa. |
| Databáze: | OpenAIRE |
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