Comparison of prednisolone and dexamethasone effects in the presence of environmental control in heaves-affected horses
| Autor: | Brigitte Siliart, Guillaume Fortier, Guillaume Brachet, A. Couroucé-Malblanc, Stéphane Pronost |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Hydrocortisone Prednisolone Anti-Inflammatory Agents Gastroenterology Dexamethasone Internal medicine Cytology medicine Animals Horses Lung Diseases Obstructive General Veterinary medicine.diagnostic_test business.industry Horse Repeated measures design respiratory system Surgery Bronchoalveolar lavage Arterial blood Female Horse Diseases Animal Science and Zoology Blood Gas Analysis business Bronchoalveolar Lavage Fluid medicine.drug |
| Zdroj: | The Veterinary Journal. 175:227-233 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2006.12.006 |
| Popis: | This study was designed to compare the efficacy of oral prednisolone and intramuscular (IM) dexamethasone in heaves-affected horses with environmental control. A total of 16 horses, aged 8-20years, with heaves were included in the study. Complete examinations were performed on Day 0 (before treatment), Day 13 (after treatment) and Day 30. Clinical variables, arterial blood gases, mucus scoring and carina evaluation (during endoscopy), and bronchoalveolar lavage (BAL) cytological analysis were all assessed. The horses were randomly assigned to receive either oral prednisolone (1mg/kg) or IM dexamethasone (0.1mg/kg). The animals were clinically scored and mucus accumulation evaluated. Results were analysed by repeated measures ANOVA with time (days of treatment) and treatment as the main effects. When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores. However, dexamethasone had a more beneficial effect on BAL cytology. |
| Databáze: | OpenAIRE |
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