Autoreceptor Antagonists Enhance the Effect of the Reuptake Inhibitor Citalopram on Extracellular 5-HT: this Effect Persists After Repeated Citalopram Treatment
| Autor: | C Gundlah, S Hjorth, Sidney B. Auerbach |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Serotonin Microdialysis medicine.medical_specialty Pyridines medicine.drug_class Citalopram Pharmacology Hippocampus Piperazines Rats Sprague-Dawley Cellular and Molecular Neuroscience Prosencephalon Internal medicine medicine Animals Chromatography High Pressure Liquid Autoreceptors Brain Chemistry Chemistry Antagonist Receptor antagonist Rats Endocrinology Receptors Serotonin Autoreceptor Antidepressant 5-HT1A receptor Serotonin Antagonists Penbutolol Extracellular Space Reuptake inhibitor Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Neuropharmacology. 36:475-482 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/s0028-3908(97)00052-x |
| Popis: | The effect of repeated administration of the reuptake inhibitor citalopram (10 mg/kg s.c., b.i.d. for 14 days) or saline on extracellular 5-hydroxytryptamine (5-HT) and autoreceptor sensitivity was assessed using microdialysis in the frontal cortex (FCx) and dorsal hippocampus (DH) of unanesthetized rats. Acute citalopram (5 mg/kg s.c.) challenge produced significant increases in DH and FCx 5-HT. The nonselective 5-HT1A/1B receptor antagonist (-)+penbutolol (8 mg/kg s.c.), administered 2 hr after citalopram challenge, significantly enhanced 5-HT in FCx and DH of both the chronic citalopram and saline pretreatment groups. Administration of the selective 5-HT1A receptor antagonist WAY 100635 (0.3 mg/kg s.c.) after citalopram challenge significantly enhanced 5-HT in FCx but not DH of both pretreatment groups. This suggests that there may be differences between DH and FCx in regulation of 5-HT release. Nevertheless, these results provide evidence that 5-HT autoreceptors are still active in restraining 5-HT release. Nevertheless, these results provide evidence that 5-HT autoreceptors are still active in restraining 5-HT release even after repeated administration of an antidepressant drug. |
| Databáze: | OpenAIRE |
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