| Autor: |
N. V. Petrova, A. G. Emelyanova, S. A. Tarasov, Е. А. Glubokova, N. P. Каrtashova |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Bulletin of experimental biology and medicine. |
| ISSN: |
1573-8221 |
| Popis: |
The antiviral activity of technologically processed antibodies to CD4 receptor was evaluated a model of sublethal A/California/04/2009 (H1N1)pdm09-induced influenza infection in female BALB/c mice. The technologically processed antibodies increased animal survival rate by 50% in comparison with the placebo group (p0.05), which correlated with significant inhibition of virus replication in the lungs (p0.05). The reference drug Tamiflu increased mouse survival rate (by 47%), decreased the virus titer in the lungs, and prevented body weight loss (p0.05 in comparison with the placebo group by all parameters). The intrinsic protective activity of technologically processed antibodies to CD4 receptor was demonstrated, which manifested in a decrease in viral load in the lower respiratory tract and an increase in the survival rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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