Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status
| Autor: | V Seshiah, Madhuri S. Balaji, Caryn K. Snyder, Srinivasa R. Nagalla, V. Balaji, Paturi V. Rao, John Edward A. Michaels, Mary J Laughlin, Charles T. Roberts |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Screening test endocrine system diseases Offspring Endocrinology Diabetes and Metabolism Brief Communication lcsh:Diseases of the endocrine glands. Clinical endocrinology Endocrinology Serum biomarkers Diabetes mellitus medicine maternal serum biomarker lcsh:RC799-869 Gestational diabetes Pregnancy lcsh:RC648-665 Obstetrics business.industry nutritional and metabolic diseases medicine.disease Obesity female genital diseases and pregnancy complications glycosylated fibronectin lcsh:Diseases of the digestive system. Gastroenterology business Risk assessment |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 19, Iss 1, Pp 155-159 (2015) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | The prevalence of gestational diabetes mellitus (GDM) is increasing because of the worldwide obesity/diabetes epidemic. The complications of untreated GDM affect both the mother and baby and include complications during pregnancy as well as increased risk of subsequent type-2 diabetes in mothers and offspring. Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (HbA1c), are currently not recommended for GDM screening. Instead, an oral glucose tolerance test is specified, which is invasive, time-consuming, and not easily accessible to many at-risk populations. In this study, we describe a multi-analyte maternal serum profile test that incorporates novel glycoprotein biomarkers and previously described GDM-associated markers. In screening for GDM by multi-analyte panel, the detection rate was 87% at a false-positive rate of 1%. |
| Databáze: | OpenAIRE |
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