Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients
| Autor: | Ioannis Kallikazaros, Costas Tsioufis, Ioannis Skiadas, Christodoulos Stefanadis, Dimitrios Tousoulis, Maria Selima, Costas Thomopoulos, Kyriakos Dimitriadis, Costas Mihas |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Essential hypertension Risk Factors Internal medicine medicine.artery medicine Humans Pulse wave velocity Aorta Aortitis biology Adiponectin business.industry C-reactive protein Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease C-Reactive Protein Blood pressure Endocrinology Hypertension biology.protein Arterial stiffness Female Aortic stiffness Cardiology and Cardiovascular Medicine business Biomarkers Compliance |
| Zdroj: | European Heart Journal. 28:1162-1169 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehm089 |
| Popis: | Aims In this study, we investigated the combined effect of increased high-sensitivity C-reactive protein (hs-C-reactive protein) and hypoadiponectinaemia on aortic stiffness in essential hypertensive subjects. Methods and results A total of 267 untreated patients with stage I–II essential hypertension underwent ambulatory BP and carotid–femoral pulse wave velocity (c–f PWV) evaluation. The distributions of hs-C-reactive protein and adiponectin were split by the median (1.3 mg/L and 7.8 µg/mL, respectively) and accordingly subjects were stratified into those with high and low values. Patients with high ( n = 134) compared with those with low hs-C-reactive protein ( n = 133) values exhibited greater c–f PWV levels (by 0.8 m/s, P < 0.0001), whereas patients with low ( n = 133) compared with those with high ( n = 134) adiponectin levels had higher c–f PWV (by 0.9 m/s, P < 0.0001). Stepwise regression analysis revealed that age, 24 h systolic BP, hs-C-reactive protein and adiponectin were independent predictors of arterial stiffness. In patients with low hs-C-reactive protein, hypoadiponectinaemia ( n = 46) compared with high adiponectin ( n = 87) was accompanied by increased c–f PWV (by 0.8 m/s, P < 0.0001). Similarly in patients with high hs-C-reactive protein, hypoadiponectinaemia ( n = 84) compared with high adiponectin ( n = 50) was related to heightened c–f PWV (by 0.7 m/s, P = 0.008). Conclusion In essential hypertension, pronounced low-grade inflammation in conjunction with hypoadiponectinaemia exerts an additive detrimental effect on aortic stiffness, accelerating the vascular ageing process. |
| Databáze: | OpenAIRE |
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