Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells
| Autor: | Sarah E. Millar, Thomas Andl, Damon de la Cruz, Chih Chiang Chen, Maksim V. Plikus, Randall B. Widelitz, Philip K. Maini, Cheng-Ming Chuong, Clyde Fare, Ruth E. Baker |
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| Rok vydání: | 2011 |
| Předmět: |
Transgene
Population Mice Transgenic Biology Bone morphogenetic protein Models Biological Article Mice medicine Animals Regeneration Computer Simulation education Stochastic Processes education.field_of_study Multidisciplinary Activator (genetics) Stem Cells Wnt signaling pathway Hair follicle Cell biology Mice Inbred C57BL Wnt Proteins medicine.anatomical_structure Bone Morphogenetic Proteins Immunology Rabbits Signal transduction Stem cell Hair Follicle Signal Transduction |
| Zdroj: | Science. 332:586-589 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1201647 |
| Popis: | Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs. |
| Databáze: | OpenAIRE |
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