Implantable antimicrobial biomaterials for local drug delivery in bone infection models
| Autor: | Jeremy D. Caplin, Andrés J. García |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
0206 medical engineering Biomedical Engineering Biocompatible Materials 02 engineering and technology Bacterial Physiological Phenomena Biochemistry Article Biomaterials Bone Infection Anti-Infective Agents medicine Animals Humans Intensive care medicine Molecular Biology Drug Implants Bacteria business.industry Osteomyelitis Critical factors Implant failure Bacterial Infections General Medicine Bone Diseases Infectious 021001 nanoscience & nanotechnology Bone defect Antimicrobial medicine.disease 020601 biomedical engineering Biofilms Drug delivery Implant 0210 nano-technology business Biotechnology |
| Zdroj: | Acta Biomater |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2019.01.015 |
| Popis: | Increased use of implantable biomedical devices demonstrates their potential in treating a wide variety of ailments and disorders in bone trauma and orthopaedic, reconstructive, and craniofacial applications. However, the number of cases involving implant failure or malfunction due to bacterial infection have also increased in recent years. Implanted devices can facilitate the growth of bacteria as these micro-organisms have the potential to adhere to the implant and grow and develop to form biofilms. In an effort to better understand and mitigate these occurrences, biomaterials containing antimicrobial agents that can be released or presented within the local microenvironment have become an important area of research. In this review, we discuss critical factors that regulate antimicrobial therapy to sites of bone infection, such as key biomolecular considerations and platforms for delivery, as well as current in vivo models and current advances in the field. STATEMENT OF SIGNIFICANCE: This review outlines the important factors that are taken into consideration for the development of biomaterials for local delivery of therapeutics to the site of bone infections. An overview of important criteria for development of this model (such as type of bone defect, antimicrobial therapeutic, and delivery vehicle) are provided, along with current research that utilizes these considerations. Additionally, this review highlights recent clinical trials that have utilized antimicrobial therapeutics for treatment of osteomyelitis. |
| Databáze: | OpenAIRE |
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