Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck
| Autor: | Martin J. Shearer, L. Bitensky, SJ Hodges, A. Catterall, T.C.B. Stamp, M. J. Pilkington, J. Chayen |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Vitamin K Histology Physiology Endocrinology Diabetes and Metabolism Osteoporosis chemistry.chemical_compound Internal medicine medicine Humans In patient Rachis Aged Femoral neck Aged 80 and over business.industry Vitamin K2 Glutamate receptor Vitamin K 2 Middle Aged medicine.disease Pathophysiology Femoral Neck Fractures medicine.anatomical_structure Endocrinology chemistry Spinal Fractures Female business |
| Zdroj: | Bone. 12:387-389 |
| ISSN: | 8756-3282 |
| Popis: | Vitamin K1 functions in the conversion of glutamate residues, present in certain bone peptides, into the putatively active gamma-carboxyglutamate form. We have shown previously that the circulating levels of vitamin K1 are depressed in osteoporotic patients. However, it is known that menaquinones (vitamin K2:MK) may be more effective than vitamin K1 in this conversion of the inactive to active form of glutamate residues. A procedure for measuring such menaquinones has now demonstrated a marked deficiency of MK-7 and MK-8 in patients with osteoporotic fractures. It is suggested that estimates of circulating levels of K1, MK-7, and MK-8 might provide a biochemical risk marker of osteoporotic fractures. |
| Databáze: | OpenAIRE |
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