Efficacy of Three Commercial Disinfectants in Reducing Microbial Surfaces' Contaminations of Pharmaceuticals Hospital Facilities
| Autor: | Chiara Di Bartolo, Francesco Monaco, Bruno Douradinha, Giuseppina Di Martino, Danilo D'Apolito, Salvatore Pasqua, Pier Giulio Conaldi |
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| Rok vydání: | 2020 |
| Předmět: |
validation
Health Toxicology and Mutagenesis Disinfectant lcsh:R efficacy surface contaminations Public Health Environmental and Occupational Health lcsh:Medicine 030501 epidemiology Contamination Pulp and paper industry Hospitals Article Disinfection 03 medical and health sciences 0302 clinical medicine Pharmaceutical Preparations Environmental science Humans disinfection procedure 030212 general & internal medicine 0305 other medical science disinfectant Log10 reduction Disinfectants |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 779, p 779 (2021) Volume 18 Issue 2 |
| ISSN: | 1660-4601 |
| Popis: | To evaluate and validate the efficacy of disinfectants used in our cleaning procedure, in order to reduce pharmaceutical hospital surfaces&rsquo contaminations, we tested the action of three commercial disinfectants on small representative samples of the surfaces present in our hospital cleanrooms. These samples (or coupons) were contaminated with selected microorganisms for the validation of the disinfectants. The coupons were sampled before and after disinfection and the microbial load was assessed to calculate the Log10 reduction index. Subsequently, we developed and validated a disinfection procedure on real surfaces inside the cleanrooms intentionally contaminated with microorganisms, using approximately 107&ndash 108 total colony forming units per coupon. Our results showed a bactericidal, fungicidal, and sporicidal efficacy coherent to the acceptance criteria suggested by United States Pharmacopeia 35 < 1072> The correct implementation of our cleaning and disinfection procedure, respecting stipulated concentrations and contact times, led to a reduction of at least 6 Log10 for all microorganisms used. The proposed disinfection procedure reduced the pharmaceutical hospital surfaces&rsquo contaminations, limited the propagation of microorganisms in points adjacent to the disinfected area, and ensured high disinfection and safety levels for operators, patients, and treated surfaces. |
| Databáze: | OpenAIRE |
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