Resection of hepatocellular carcinoma in elderly patients and the role of energy balance
| Autor: | Michele Ruggiero, Marco Cannistrà, Matteo Novello, Raffaele Grande, Giuseppe Cavallari, E. Bonaiuto, Alessandra Zullo, Raffaele Serra, Bruno Nardo, S. Vaccarisi |
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| Přispěvatelé: | Cannistrã , Marco, Grande, Raffaele, Ruggiero, Michele, Novello, Matteo, Zullo, Alessandra, Bonaiuto, Elisabetta, Vaccarisi, Sebastiano, Cavallari, Giuseppe, Serra, Raffaele, Nardo, Bruno |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pleural effusion Health Services for the Aged medicine.medical_treatment Atorvastatin Bed rest Gastroenterology 0302 clinical medicine Postoperative Complications Risk Factors Hospital Mortality Postoperative Period HCC Fatigue Liver Neoplasms General Medicine Italy Liver Neoplasm 030220 oncology & carcinogenesis Hepatocellular carcinoma Female Elderly patient Human medicine.drug medicine.medical_specialty Carcinoma Hepatocellular Neutropenia 03 medical and health sciences Internal medicine Diabetes mellitus Coenzyme Q10 Elderly patients Liver failure Statins Aged Hepatectomy Humans Length of Stay medicine business.industry Risk Factor Statin Perioperative medicine.disease Surgery 030104 developmental biology Postoperative Complication business |
| Zdroj: | International journal of surgery (London, England). 33 |
| ISSN: | 1743-9159 |
| Popis: | Introduction Progressive functional impairment with age has a significant impact on perioperative risk management. Chronic liver diseases induce a strong oxidative stress; in the elderly, in particular, impaired elimination of free radicals leads to insufficient DNA repair. The events associated with a weak response to growth factors after hepatectomy leads to a decline in liver regeneration. Hypercholesterolemia is highly prevalent in the elderly, which may alter the coenzyme Q10 (CoQ) levels and in turn the cellular energy balance. This condition is commonly treated with statins. The aim of this study is to investigate the role of preoperative cellular energy balance in predicting hepatocellular carcinoma (HCC) postresection outcomes. Materials and methods In a 5-year period (2009–2013), elderly patients with hypercholesterolemia, cardiovascular disease, and diabetes mellitus, undergoing HCC resection, were recruited and grouped by age ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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