Urea Rebound Assessment Based on UV Absorbance in Spent Dialysate
| Autor: | Fredrik Uhlin, Ruth Tomson, Ivo Fridolin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_treatment Uv absorbance Biomedical Engineering Biophysics Bioengineering Biomaterials Young Adult chemistry.chemical_compound Renal Dialysis Dialysis Solutions Spectrophotometry medicine Humans Urea Aged Aged 80 and over Chromatography medicine.diagnostic_test Chemistry General Medicine Middle Aged Urea blood Female Spectrophotometry Ultraviolet Hemodialysis |
| Zdroj: | ASAIO Journal. 60:459-465 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/mat.0000000000000091 |
| Popis: | The aim of the study was to examine the possibility of postdialysis urea rebound assessment using UV-absorbance measurements in spent dialysate. Twenty-six patients on chronic three-times-a-week hemodialysis (HD) were studied in two separate studies. Double-beam spectrophotometer was used for the determination of UV absorbance in the collected spent dialysate samples. Also, on-line UV absorbance was monitored. The equilibrium concentration (C(eq)) of urea at the end of the rebound phase was calculated based on urea concentration in blood and dialysate and UV absorbance in spent dialysate. Based on C(eq), urea rebound was expressed relative to urea concentration at the end of HD (R1) and relative to the decrease in urea concentration during HD (R2). Estimates based on UV-absorbance values in spent dialysate (R(1_a), R(2_a)) slightly over assess postdialysis rebound compared with results based on the blood sample drawn 30 min after HD (R(1_30post), R(2_30post)), but R(1_a) and R(2_a) presented greater consistency and accuracy compared with the estimates based on the intradialytic blood sample (R(1_b), R(2_b)). In summary, the results show that it is possible to assess postdialysis urea rebound in blood based on UV-absorbance measurements in spent dialysate. |
| Databáze: | OpenAIRE |
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