Drug delivery strategies for curcumin and other natural Nrf2 modulators of oxidative stress-related diseases
| Autor: | Nina Katarina Grilc, Matej Sova, Julijana Kristl |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
nanodelci
kurkumin micelles SMEDDS Pharmaceutical Science Review slaba topnost resveratrol samo(mikro)emulgirajoči sistem micele RS1-441 poor solubility Pharmacy and materia medica Nrf2 modulator solid dispersions udc:542:612.015 oral bioavailability peroralna biološka uporabnost oksidativni stres oxidative stress curcumin nanoparticles trdne disperzije |
| Zdroj: | Pharmaceutics, vol. 13, no. 12, 2137, 2021. Pharmaceutics Pharmaceutics, Vol 13, Iss 2137, p 2137 (2021) |
| ISSN: | 1999-4923 |
| Popis: | Oxidative stress is associated with a wide range of diseases characterised by oxidant-mediated disturbances of various signalling pathways and cellular damage. The only effective strategy for the prevention of cellular damage is to limit the production of oxidants and support their efficient removal. The implication of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the cellular redox status has spurred new interest in the use of its natural modulators (e.g., curcumin, resveratrol). Unfortunately, most natural Nrf2 modulators are poorly soluble and show extensive pre-systemic metabolism, low oral bioavailability, and rapid elimination, which necessitates formulation strategies to circumvent these limitations. This paper provides a brief introduction on the cellular and molecular mechanisms involved in Nrf2 modulation and an overview of commonly studied formulations for the improvement of oral bioavailability and in vivo pharmacokinetics of Nrf2 modulators. Some formulations that have also been studied in vivo are discussed, including solid dispersions, self-microemulsifying drug delivery systems, and nanotechnology approaches, such as polymeric and solid lipid nanoparticles, nanocrystals, and micelles. Lastly, brief considerations of nano drug delivery systems for the delivery of Nrf2 modulators to the brain, are provided. The literature reviewed shows that the formulations discussed can provide various improvements to the bioavailability and pharmacokinetics of natural Nrf2 modulators. This has been demonstrated in animal models and clinical studies, thereby increasing the potential for the translation of natural Nrf2 modulators into clinical practice. |
| Databáze: | OpenAIRE |
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