The importance of sPD-1, sOX40L and sGITR in terms of clinicopathology and histopathology in gastric cancer
| Autor: | Soykan Arikan, Ozlem Kucukhuseyin, Mehmet Tolgahan Hakan, Dilara Sonmez, Cem Horozoglu, Ilhan Yaylim, Seyda Demirkol |
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| Přispěvatelé: | Tıp Fakültesi |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology business.industry Biochemistry (medical) Clinical Biochemistry Cancer medicine.disease Biochemistry Sox40l Signetring Cell Carcinoma Gastric Cancer 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Signet ring cell carcinoma Spd-1 medicine Histopathology Sgitr business Molecular Biology |
| Zdroj: | Turkish Journal of Biochemistry. 46:273-279 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2020-0075 |
| Popis: | Objectives Immunoregulatory GITR, OX40L and PD-1 molecules play an active role in the regulation of tumor microenvironment and have been shown in many cancer types. However, there are limited studies of these molecules in terms of gastric cancer. In our study, we aimed to determine the histopathological significance of sPD-1, sOX40L and sGITR levels in gastric cancer cases. Methods Serum samples were obtained from peripheral blood samples of 20 gastric cancer and 34 healthy controls and candidate biomarker levels were determined by ELISA. Results sGITR level was found to be 48.28 ± 2.66 pg/mL in the gastric cancers and 39.19 ± 2.01 pg/mL in the controls (p=0.014). sOX40L level was 6.13 ± 0.64 pg/mL in the patients and 8.68 ± 0.99 pg/mL in the control, and the sOX40L level was found to be 1.41 times higher in the control group compared to the patients (p=0.033). sGITR levels of signet-ring cell carcinoma were found to be higher than other adenocarcinomas (p=0.04). There was no difference between groups in sPD-1 (p=0.490). Conclusions We suggest that sGITR, sOX40L and molecules may play a role in tumor microenvironment regulation and histological type in gastric cancer. |
| Databáze: | OpenAIRE |
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