Bone Mineral Density in Children and Young Adults with Crohnʼs Disease
| Autor: | David A. Piccoli, Edisio Semeao, Virginia A. Stallings, Kristin M. Neiswender, Babette S. Zemel, Abbas F. Jawad |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Adolescent Bone density Growth Absorptiometry Photon Crohn Disease Bone Density Age Determination by Skeleton Internal medicine Prevalence medicine Humans Immunology and Allergy In patient Young adult Child Bone Demineralization Pathologic Dual-energy X-ray absorptiometry Bone mineral Analysis of Variance Crohn's disease Anthropometry medicine.diagnostic_test business.industry musculoskeletal neural and ocular physiology Puberty Gastroenterology Bone age musculoskeletal system medicine.disease Endocrinology Female business |
| Zdroj: | Inflammatory Bowel Diseases. 5:161-166 |
| ISSN: | 1078-0998 |
| Popis: | Reduced bone mineral density (BMD) has been reported in adults with Crohn's disease (CD). Less is known about abnormal BMD in children and young adults with CD. The aims of this study are to determine the prevalence of low BMD and to evaluate the effect of growth and pubertal development on BMD in children and young adults with CD. One hundred-nineteen patients with CD underwent dual-energy X-ray absorptiometry (DXA) to determine BMD. Anthropometry and pubertal development were measured. Bone age was measured only in patients older than 8 years of age and who had not grown in height during the last year. One hundred-nineteen patients (72 male, 47 female) were evaluated. Seventy percent of patients had BMD z-scores < or = -1.0 and 32% had z-scores < or = -2.0. Weight and height z-scores were significantly associated with BMD z-scores. BMD z-scores based on bone age and on chronological age were highly correlated, except when the chronological age BMD z-score was < or = -2.0. BMD z-score was significantly different between males and females for the group (-1.75 +/- 1.06 vs. -1.08 +/- 1.00), respectively. Children and young adults with CD have a high prevalence of low BMD and routine evaluation by DXA is indicated. In patients with a chronological age-based BMD z-score < or = -2.0, a bone age-based BMD should be considered. |
| Databáze: | OpenAIRE |
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