Sequence Analysis of env C2/V3, gag p17/p24, and pol Protease Regions of 25 HIV Type 1 Isolates from Ho Chi Minh City, Vietnam
| Autor: | Truong Xuan Lien, Marie-Hélène Schrive, Dominique Dormont, Hervé Fleury, Anne Caumont, Maria-Soledad Goni Urriza, Nguyen Thi Hoang Lan, Nguyen Thi Vy Uyen, Evelyne Schvoerer, Marie-Edith Lafon, Pham Van Hung, Pierre Roques, Françoise Barré-Sinoussi |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Adolescent Sequence analysis viruses medicine.medical_treatment Molecular Sequence Data Immunology HIV Infections V3 loop Biology Genes env Virus DNA sequencing law.invention immune system diseases law Virology medicine Humans Amino Acid Sequence Gene Phylogeny Genetics Polymorphism Genetic Protease Nucleic acid sequence Gene Products env virus diseases Genes gag Genes pol Infectious Diseases Vietnam HIV-1 Recombinant DNA Female Sequence Alignment |
| Zdroj: | AIDS Research and Human Retroviruses. 17:1285-1291 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/088922201750461357 |
| Popis: | Env C2/V3, gag p17/p24, pol protease, and RT regions of HIV-1 isolates recently obtained from 25 HIV-1 seropositive individuals from Ho Chi Minh City (Vietnam) were studied, and genes subtypes were determined by DNA sequence analyses. Twenty-three isolates out of 25 were identified as belonging to subtype E, now recognized as circulating recombinant form 1 (CRF01_AE). The motif at the top of the V3 loop (generally GPGQ) was then preceded by an isoleucine or a methionine (M) residue; the M residue might be a local signature of Vietnamese E isolates compared to Thai E viruses. Two isolates (8%) were shown to be intersubtype recombinants: one E/B and one CRF02_AG(IBNG)/D. The polymorphism of pol protease was considered only for CRF01_AE isolates and is clearly different from that recorded for B viruses with substitutions at positions 13, 35, 36, 41, 69, and 89. |
| Databáze: | OpenAIRE |
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