Variability of plasma homovanillic acid over 13 months in patients with schizophrenia; relationship with the clinical response and the Wisconsin card sort test
| Autor: | Aurora Arrúe, Miguel Angel Gonzalez-Torres, Lucía Inchausti, Ricardo Dávila, Mercedes Zumárraga, Sonia Bustamante, Nieves Basterreche, Aranzazu Fernandez-Rivas, Lucía Pérez-Cabeza, Wendy Dávila, José Guimón |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Neuropsychological Tests Biochemistry Pharmacological treatment Cellular and Molecular Neuroscience chemistry.chemical_compound Young Adult Internal medicine Brief Psychiatric Rating Scale medicine Humans In patient Psychiatry Psychiatric Status Rating Scales Homovanillic acid Homovanillic Acid General Medicine medicine.disease chemistry Schizophrenia Psychiatric status rating scales Female Wisconsin card sort test Psychology Antipsychotic Agents |
| Zdroj: | Neurochemical research. 36(8) |
| ISSN: | 1573-6903 |
| Popis: | In the present study we have measured, on a monthly basis, the concentration of plasma homovanillic acid (pHVA) in schizophrenic patients during 13 months of their pharmacological treatment. The average pHVA values of each patient were within the range of 7.30–17.70 ng/ml and the coefficients of variation for each patient (CV %) were within the range of 13–33%. Half of the patients that showed higher pHVA CV% values also showed higher scores on the Brief Psychiatric Rating Scale at the beginning of the study, and improved more after 6 months, when compared to the remaining 50% with lower CV% values. There was no significant relationship between the scores of the Wisconsin Card Sort Test and the concentration or the CV% of the pHVA of each patient. A greater variability in the pHVA may be associated with a greater plasticity of the dopaminergic system and a better clinical response. |
| Databáze: | OpenAIRE |
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