Genotoxic and cytotoxic assessment of two endemic Lamiaceae species from Bosnia and Herzegovina
| Autor: | Sanja Ćavar Zeljković, Sanin Haverić, Maida Hadžić, Jasmina Čakar, Tamara Ćetković, Mahira Mehanović, Anja Haverić |
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| Rok vydání: | 2021 |
| Předmět: |
Bosnia and Herzegovina
Lamiaceae food.ingredient biology Traditional medicine Plant Extracts 010405 organic chemistry Organic Chemistry Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry food Phenols Clinopodium alpinum Humans Cytotoxic T cell Dimethyl Sulfoxide Thymus bracteosus Orontium DNA Damage |
| Zdroj: | Natural Product Research. 36:2888-2892 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Clinopodium alpinum subsp. orontium (K.Malý) Govaerts and Thymus bracteosus Vis. ex Benth. are endemic Lamiaceae species in Bosnia and Herzegovina with rather limited data about their cytotoxic and genotoxic effects. This study aimed to analyse phenolic compounds composition of C. alpinum subsp. orontium and T. bracteosus aqueous and dimethyl sulphoxide (DMSO) extracts and their cytotoxic and genotoxic potential in human peripheral blood lymphocyte cultures. Among 33 analytes, 17 were identified and quantified in the examined extracts with the rosmarinic and chlorogenic acids as main constituents. Genotoxic effects of extracts from both species are proven at the highest applied dose. T. bracteosus extracts and DMSO as a solvent exhibited stronger genotoxic potential that should be further investigated in tumour cell lines. Nevertheless, non-endemic species with similar phenolic composition and bioactivity should be the first choice for medicinal purposes. |
| Databáze: | OpenAIRE |
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