Inhibition of human macrophage colony formation by interleukin 4
| Autor: | Willem E. Fibbe, Roelof Willemze, G. J. H. M. Wientjens, Hanneke C. Kluin-Nelemans, J. H. Jansen |
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| Rok vydání: | 1989 |
| Předmět: |
Macrophage colony-stimulating factor
medicine.medical_specialty Immunology Antigen-Presenting Cells Bone Marrow Cells In Vitro Techniques Biology Colony-Stimulating Factors Internal medicine medicine Humans Immunology and Allergy Progenitor cell Antigen-presenting cell Interleukin 4 Interleukins Macrophage Colony-Stimulating Factor Macrophages Monocyte Granulocyte-Macrophage Colony-Stimulating Factor Articles Molecular biology Growth Inhibitors Recombinant Proteins Hematopoiesis Haematopoiesis Granulocyte macrophage colony-stimulating factor Endocrinology medicine.anatomical_structure Interleukin-4 Bone marrow medicine.drug |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.170.2.577 |
| Popis: | We investigated the effects of human rIL-4 on in vitro hematopoiesis. A profound inhibition of macrophage colony formation by IL-4 was observed, whereas colony growth of other lineages was not affected. Inhibition of macrophage colony growth was not restricted to GM-CSF-induced colony growth but was also present in cultures stimulated with M-CSF. This inhibition was not only observed in cultures of light density bone marrow cells, but also in cultures of monocyte- and T lymphocyte-depleted bone marrow cells. Since a similar inhibition was observed in cultures of CD34+HLA-DR+-enriched bone marrow cells, a direct action of IL-4 on monocyte-committed progenitor cells is suggested. |
| Databáze: | OpenAIRE |
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