M2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and Epstein-Barr viral infection in nasopharyngeal carcinoma
| Autor: | Feipeng Zhao, Bao Zhang, Meng-Wen Zhang, Xiang-Ping Li, Gang Li, Juan Lu, Xiaomei Chen, Xiaohong Peng, Xiong Liu, Haoran Huang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Poor prognosis China Epstein-Barr Virus Infections Herpesvirus 4 Human Antigens Differentiation Myelomonocytic Cell Count Receptors Cell Surface Biology medicine.disease_cause Viral infection 03 medical and health sciences 0302 clinical medicine Stroma Antigens CD otorhinolaryngologic diseases medicine Humans In Situ Hybridization Nasopharyngeal Carcinoma Macrophages Carcinoma Nasopharyngeal Neoplasms General Medicine Middle Aged medicine.disease Prognosis Epstein–Barr virus Immunohistochemistry stomatognathic diseases 030104 developmental biology Otorhinolaryngology Nasopharyngeal carcinoma Epstein barr 030220 oncology & carcinogenesis Clinicopathological features RNA Viral Female CD163 |
| Zdroj: | Acta oto-laryngologica. 137(8) |
| ISSN: | 1651-2251 |
| Popis: | To assess the relationships between CD163 expression, localization of CD163A total of 110 cases of NPC specimens and 80 cases of nasopharyngitis specimens were analysed for CD163 expression by immunohistochemistry and EBERs expression in situ hybridization.CD163 + macrophages in the tumour stroma were positively correlated with the tumour and nodal stage. Higher expression of Epstein-Barr virus-encoded RNAs (EBERs) in the nuclei of tumour cells was associated with higher density of CD163 + macrophages in the tumour stroma. More importantly, greater infiltration of CD163 + macrophages in the tumour stroma was associated with poor overall survival (OS) and poor progression-free survival (PFS). Multivariate analysis revealed that the density of CD163Increased infiltration of CD163 |
| Databáze: | OpenAIRE |
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