Solitary Fibrous Tumor of the Thyroid Gland
Autor: | Xavier Matias-Guiu, Enrique Ayala, Antonio L. Cubilla, Carmelo Caballero, Juan Rosai, Concepción De Miguel, Ingrid Rodriguez |
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Rok vydání: | 2001 |
Předmět: |
Adenoma
Adult Male Thyroiditis Solitary fibrous tumor Pathology medicine.medical_specialty Soft Tissue Neoplasm Neoplasms Fibrous Tissue Antigens CD34 12E7 Antigen Pathology and Forensic Medicine Diagnosis Differential Thyroid carcinoma Antigens CD medicine Carcinoma Humans Mesenchymoma Neoplasms Glandular and Epithelial Thyroid Neoplasms Anaplastic carcinoma Aged business.industry Thyroid Anatomy Middle Aged medicine.disease Immunohistochemistry Carcinoma Papillary medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Female Surgery business Cell Adhesion Molecules Follow-Up Studies |
Zdroj: | The American Journal of Surgical Pathology. 25:1424-1428 |
ISSN: | 0147-5185 |
Popis: | Solitary fibrous tumor is a soft tissue neoplasm initially described in the pleura but subsequently reported in a wide variety of locations. The clinical behavior is usually benign, but the existence of aggressive cases has been documented both in the pleura and in extrapleural sites. In this report clinical and pathologic features of seven solitary fibrous tumors of the thyroid gland are presented. Patients' ages ranged from 43 to 64 years (mean 52 years), and tumor sizes varied from 2 to 6 cm. Grossly, the tumors were white-tan and well circumscribed. Microscopically, there was a variegated, wavy, storiform, hemangiopericytic or desmoid-like arrangement of spindle cells. Trapped thyroid follicles within the tumor and peripheral jagged tumor infiltration among follicles were common. There was immunohistochemical reactivity for CD34, CD99, and bcl-2, and ultrastructural analysis of one tumor was consistent with a fibroblastic lineage. The differential diagnosis included other benign and malignant mesenchymal tumors of the thyroid, spindle cell follicular adenoma, Riedel's thyroiditis, the spindle cell, and paucicellular variants of anaplastic carcinoma, papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma, and the spindle epithelial tumor with thymus-like differentiation. The cumulative data of 13 cases (comprised of the seven present cases and the six previously reported) suggest a benign clinical behavior for thyroid SFT. |
Databáze: | OpenAIRE |
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