PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
| Autor: | William C. Eckelman, Marianna Spanaki, L. Lang, William H. Theodore, Maria T. Toczek, Margaret G. Der, S. Fazilat, Peter Herscovitch, Y. Ma, Leonid Kopylev, Richard E. Carson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pyridines Hippocampus Piperazines Temporal lobe Epilepsy Radioligand Humans Medicine Tissue Distribution Ictal Raphe business.industry Middle Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe Glucose Epilepsy Temporal Lobe Cerebral blood flow Cerebrovascular Circulation Receptor Serotonin 5-HT1A 5-HT1A receptor Female Neurology (clinical) Atrophy business Nuclear medicine Tomography Emission-Computed |
| Zdroj: | Neurology. 60:749-756 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/01.wnl.0000049930.93113.20 |
| Popis: | Background: Activation of central serotonin (5-HT) 1A receptors, found in high density in brainstem raphe, hippocampus, and temporal neocortex, exerts an anticonvulsant effect in various experimental seizure models. To test the hypothesis that 5-HT 1A receptor binding is reduced in human epileptic foci, PET imaging was performed using the radioligand [ 18 F]trans-4-fluoro- N -2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]- N -(2-pyridyl)cyclohexanecarboxamide ([ 18 F]FCWAY), a selective 5-HT 1A receptor antagonist, in patients with temporal lobe epilepsy and normal controls. Methods: MRI and PET were performed using [ 15 O]water and [ 18 F]FCWAY in 10 controls and in 12 patients with temporal lobe epilepsy confirmed on ictal video-EEG; patients also underwent [ 18 F]fluorodeoxyglucose PET. Using quantitative PET image analysis, regional values were obtained for [ 18 F]FCWAY volume of distribution (V), cerebral blood flow (CBF), and glucose cerebral metabolic rate (CMRglc). Hippocampal volume (HV) was also measured with MRI. [ 18 F]FCWAY V PET and MR measures were compared within patients and controls using paired t -tests; grouped comparisons were made with two sample t -tests. Results: Lower [ 18 F]FCWAY V was found ipsilateral than contralateral to the epileptic focus in inferior medial (IMT) and lateral (ILT) temporal regions of patients (ILT 47.4 ± 6.1 vs 61.8 ± 6.1, p p 18 F]FCWAY V was 29% lower in raphe and 34% lower in the ipsilateral thalamic region of patients than controls. In ILT, mean [ 18 F]FCWAY V asymmetry index (AI) was significantly greater than mean CBF and mean CMRglc AI. Mean [ 18 F]FCWAY V AI in IMT was greater than mean HV AI, but the difference was not significant. Conclusion: These findings support the hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|