Campaigns with oral polio vaccine may lower mortality and create unexpected results

Autor: Lars Hervig Jacobsen, Erliyani Sartono, Christine Stabell Benn, Amabelia Rodrigues, Peter Aaby, Ane Bærent Fisker, Hilton Whittle, Najaaraq Lund
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Short Communication
Heterologous effects
Infant mortality
Immunity
Heterologous
Non-specific effects
03 medical and health sciences
0302 clinical medicine
Poliovirus/drug effects
Sex Factors
Immunology and Microbiology(all)
medicine
Poliomyelitis/immunology
Humans
Guinea-Bissau
030212 general & internal medicine
Survival analysis
Oral polio vaccine
General Veterinary
General Immunology and Microbiology
business.industry
Mortality rate
Public Health
Environmental and Occupational Health
Infant
Poliovirus Vaccine
Oral/therapeutic use
medicine.disease
Survival Analysis
veterinary(all)
Poliomyelitis
Surgery
Poliovirus
030104 developmental biology
Infectious Diseases
Homogeneous
Censoring (clinical trials)
Poliovirus Vaccine
Oral
Molecular Medicine
Female
Sex-differential effects
business
Lower mortality
Demography
Zdroj: Benn, C S, Jacobsen, L H, Fisker, A B, Rodrigues, A, Sartono, E, Lund, N, Whittle, H C & Aaby, P 2017, ' Campaigns with oral polio vaccine may lower mortality and create unexpected results ', Vaccine, vol. 35, no. 8, pp. 1113–1116 . https://doi.org/10.1016/j.vaccine.2016.11.006
Vaccine
Vaccine, 35(8), 1113-1116
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2016.11.006
Popis: Three studies from Guinea-Bissau found conflicting effects of OPV-at-birth (OPV0) on child survival. One study from 2004 suggested excess male mortality among children receiving OPV0 compared with children receiving NoOPV0 during a period of shortage of OPV. However, two subsequent studies showed beneficial effects of OPV0. In 2004, two national OPV-campaigns had been conducted in Guinea-Bissau. In a reanalysis of the 2004-study, in a survival analysis the age-adjusted mortality rate of study participants was 67% (95% CI = 42–81%) lower after the OPV-campaigns than before the campaigns. In the OPV0 group only 22% (655/3031 person-years (pyrs)) of follow-up time was “after” the OPV-campaigns whereas 55% (473/859 pyrs) of the time in the NoOPV0 group was post-campaign (p < 0.0001, Chi2). Censoring for OPV-campaigns in the original study removed excess male mortality and made the three studies more homogeneous. Overall, there is now considerable evidence that OPV, like other live vaccines, has important beneficial non-specific effects.
Databáze: OpenAIRE
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