Immunoglobulin A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in a patient with atypical bullous pemphigoid
| Autor: | Nobuyasu Mayuzumi, Takashi Hashimoto, Shigaku Ikeda, Fumi Yamaki |
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| Rok vydání: | 2010 |
| Předmět: |
Immunoglobulin A
Envoplakin Pemphigoid medicine.medical_specialty Pathology Prednisolone Dermatology Basement Membrane Pemphigoid Bullous medicine Humans Protein Precursors skin and connective tissue diseases Periplakin Autoantibodies Aged 80 and over integumentary system biology business.industry Desmoglein 1 Plakins Autoantibody Membrane Proteins General Medicine medicine.disease eye diseases biology.protein Female sense organs Bullous pemphigoid Antibody business Dapsone |
| Zdroj: | The Journal of Dermatology. 37:255-258 |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/j.1346-8138.2010.00801.x |
| Popis: | Bullous pemphigoid is an autoimmune subepidermal blistering disease associated with autoantibodies against BP180 and BP230. We report herein a rare case of bullous pemphigoid with newly formed annular erythematous lesions when bullous skin lesions were in remission. Various immunological studies revealed immunoglobulin (Ig)A antibodies against desmoglein 1, envoplakin, periplakin and BP230 in addition to IgG antibodies against BP180 and BP230. These clinical and immunological changes in a patient are a rare event, suggesting an epitope-spreading phenomenon. |
| Databáze: | OpenAIRE |
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