Comparison of insulin and proinsulin storage in an islet adenoma and adjacent pancreas
| Autor: | Edward T. Wong, Arnold W. Lindall, Michael W. Steffes |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Adenoma Tolbutamide Endocrinology Diabetes and Metabolism medicine.medical_treatment Radioimmunoassay digestive system Islets of Langerhans Endocrinology Internal medicine medicine Humans Insulin Secretion Proinsulin geography geography.geographical_feature_category Chemistry nutritional and metabolic diseases Middle Aged Adenoma Islet Cell Islet medicine.disease Insulin oscillation medicine.anatomical_structure Amylases Chromatography Gel Electrophoresis Polyacrylamide Gel Pancreas hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Metabolism. 23:249-256 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(74)90063-8 |
| Popis: | The storage of insulin and proinsulin in various subcellular compartments of an islet adenoma and islets from the adjacent pancreas was compared. The tumor had a greater concentration of proinsulin relative to insulin in the secretion granule fraction than the adjacent islets. The microsome fraction from both the adenoma and islets had a larger percentage of proinsulin compared to insulin in contrast to other fractions. In a tolbutamide tolerance test before surgery, the percentage of serum proinsulin relative to insulin was 53% before and 17% after tolbutamide. Proinsulin secretion was temporally separated from insulin secretion in the early phase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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